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pentobarbital will increase the amount or impact of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of ivosidenib with solid CYP3A4 inducers lowered ivosidenib plasma concentrations.pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A